On 1st March 1881, the Russian Tsar, Alexander II, was travelling through the snow to the Winter Palace in St Petersburg. An armed Cossack sat with the coach driver, another six Cossacks followed on horseback and behind them came a group of police officers in sledges. It was the day that the Tsar, known for his liberal reforms, had signed a document granting the first ever constitution to the Russian people. But his journey was being watched by a group of radicals called 'Narodnaya Volya' or 'The People's Will'. On a street corner near the Catherine Canal, they hurled the first of their bombs to halt the Tsar's iron-clad coach. When Alexander ignored advice and ventured out onto the snow to comfort his dying Cossacks, he was killed by another bomber who took his own life in the blast.

According to legend, the origins of the Aztec empire lie on a mythical island called Aztlan - "place of the white herons" - in the north of Mexico. From there this nomadic group of Mesoamericans are said to have undertaken a pilgrimage south to the fertile valleys of Central America. In the space of just 200 years, they formed what has been called the largest, and arguably the most ruthless, pre-Hispanic empire in North America which, at its zenith, was to rule over approximately 500 small states, comprising by the 16th century some 6 million people.

Melvyn Bragg discusses the Baroque - a term used to describe a vast array of painting, music, architecture and sculpture from the 17th and 18th centuries. His guests this week are Tim Blanning, Professor of Modern European History and Fellow of Sidney Sussex College, University of Cambridge; Nigel Aston, Reader in Early Modern History at the University of Leicester; and Helen Hills, Professor of Art History at the University of York

Despite dissections of brains both human and animal throughout the following centuries, in 1669 the Danish anatomist, Nicolaus Steno, still lamented that, “the brain, the masterpiece of creation, is almost unknown to us.” Why was the brain seen as a mystery for so long and how have our perceptions of how it works and what it symbolises changed over the centuries?

Melvyn Bragg is joined by Juliette Wood, Mariner Warner and Tony Phelan to discuss the weird and wonderful worlds of the Brothers Grimm

Around 400 BC a great swathe of Western Europe from Ireland to Southern Russia was dominated by one civilisation. Perched on the North Western fringe of this vast Iron Age culture were the British who shared many of the religious, artistic and social customs of their European neighbours. These customs were Celtic and this civilisation was the Celts.

The Consolation of Philosophy was read widely and a sense of consolation is woven into many philosophical ideas, but what for Boethius were the consolations of philosophy, what are they more generally and should philosophy lead us to consolation or lead us from it?

Nestled on a bend of the River Rhine, in the South West corner of Germany, is the City of Worms. It’s one of the oldest cities in central Europe; it still has its early city walls, its 11th century Romanesque cathedral and a 500-year-old printing industry, but in its centre is a statue of the monk, heretic and founder of the Protestant Reformation, Martin Luther. In 1521 Luther came to Worms to explain his attacks on the Catholic Church to the Holy Roman Emperor, Charles V, and the gathered dignitaries of the German lands. What happened at that meeting, called the Diet of Worms, tore countries apart, set nation against nation, felled kings and plunged dynasties into suicidal bouts of infighting.

At its peak, its influence stretched from western India to eastern China via the farthest reaches of the Indonesian archipelago. It had a fleet of 130 twelve hundred tonne ships and commanded an army of 200,000 troops that came to dominate the Indian subcontinent. It funded governments, toppled princes and generated spectacular amounts of money from trading textiles and spices. But this wasn’t an empire, it wasn’t even a state, it was a company. The East India Company, founded in 1600, lasted for 258 years before the British state gained full control of its activities. In that time it had redrawn the map of India, built an empire and reinvented the fashions and the foodstuffs of Britain.

Temujin was cast out by his tribe when he was just a child and left to struggle for survival on the harsh Steppes of what is now Mongolia. From these humble beginnings he went on to become Genghis Khan, leader of the greatest continuous land-based empire the world has ever seen. His conquered territories stretched from the Caspian Sea to the borders of Manchuria, from the Siberian forest to what is now Afghanistan. He was a charismatic commander and a shrewd military tactician. He was swift to promote those who served him well, ignoring race or creed, but vengeful to those who crossed him, killing every inhabitant of a resistant town, even the cats and dogs. Generally regarded as barbarians by their enemies, the Mongol armies were in fact disciplined and effective.

This week we explore the mammoth undertaking that was the Encyclopédie – one of its editors, D’Alembert, described its mission as giving an overview of knowledge, as if gazing down on a vast labyrinth of all the branches of human knowledge, observing where they separate or unite and even catching sight of the secret routes between them. It was a project that attracted some of the greatest thinkers of the Enlightenment - Voltaire, Rousseau and Diderot - striving to bring together all that was known of the world in one comprehensive encyclopedia. No subject was too great or too small, so while Voltaire wrote of “fantasie” and “elegance”, Diderot rolled up his sleeves and got to grips with trades and crafts, even jam-making.

By the time the exhibition closed, one quarter of the entire British population had visited Crystal Palace, the first pre-fabricated building of its kind, to marvel at an extraordinary array of exhibits amongst which were: the biggest diamond in the world, a carriage drawn by kites, furniture made of coal, and a set of artificial teeth fitted with a swivel devise which allowed the user to yawn without displacing them. Its impact was huge in terms of the development of British manufacturing, the burgeoning of a global consumer market, the development of museums and the international standing of Britain culturally and technologically. How did the Exhibition crystallise a particular moment in early Victorian Britain?

The Great Fire of London was a conflagration of unimaginable proportions – up to a third of the city was destroyed – but the burning of London, the interpretation of the fire and the arguments and ideas about what should be rebuilt give an insight into a city and a period that housed the Royal Society and the restored Stuart monarchy, a place of religious anxiety and fear of foreign invasion in a country still haunted by the Civil War.

Mevlyn Bragg discusses the Great Reform Act of 1832, a landmark on the road to British democracy. Melvyn is joined by Dinah Birch, Professor of English at Liverpool University; Michael Bentley, Professor of Modern History at the University of St Andrews; and Catherine Hall, Professor of Modern British Social and Cultural History at University College London.

Today we’re discussing the Jesuits, a Catholic religious order of priests who became known as “the school masters of Europe”. Founded in the 16th century by the soldier Ignatius Loyola, they became a major force throughout the world, from China to South America. “Give us a boy and we will return you a man, a citizen of his country and a child of God”, they declared. By the 17th century there were more than 500 schools established across Europe. Their ideas about a standardised curriculum and teaching became the basis for many education systems today.

Melvyn Bragg is joined by Simon Goldhill, Matthew Nichols and Serafina Cuomo to discuss the ancient Library of Alexandria - one of the most ambitious knowledge projects of its time

At its height, the Mughal Empire stretched from Bengal in the East to Gujarat in the West, and from Lahore in the North to Madras in the South. It covered the whole of present day northern India, Pakistan, Afghanistan and Bangladesh, and became famous for the Taj Mahal, the Koh-i-Noor and the Peacock Throne. In 1631 a Dutch naturalist Johannes de Laet published his account of the vast Empire, “the nobles live in indescribable luxury and extravagance, caring only to indulge themselves whilst they can, in every kind of pleasure. Their greatest magnificence is in their women’s quarters, for they marry three or four wives or sometimes more”.

Melvyn Bragg considers the celestial harmonies of the planets, a Pythagorean concept which fascinated astrologists, artists and mathematicians for centuries. He is joined by Peter Forshaw, Postdoctoral Fellow at Birkbeck, University of London

Why did Modern Science develop in Europe when China seemed so much better placed to achieve it? This is called the Needham Question, after Joseph Needham, the 20th century British Sinologist who did more, perhaps, than anyone else to try and explain it. Why did China’s early technological brilliance not lead to the development of modern science and how did momentous inventions like gunpowder and printing enter Chinese society with barely a ripple and yet revolutionise the warring states of Europe?

The Opium Wars between Britain and China in the 19th century forced China to open its doors to trade with the western world. The Chinese had banned opium in its various forms several times, citing concern for public morals, but the prohibition was ignored. The East India Company held a monopoly on the production of opium in British India. Private British traders continued to smuggle large quantities of opium into China. In this way, the opium trade became a way of balancing a trade deficit brought about by Britain's own addiction to tea. The Chinese protested against the flouting of the ban but the British continued to trade, leading to a crackdown by Lin Tse-Hsu, a man appointed to be China's Opium Drugs Czar. He confiscated opium from the British traders and destroyed it.

"When Adam delved and Eve span, who was then the Gentleman?" – the opening words of a rousing sermon, said to be by John Ball, which fires a broadside at the deeply hierarchical nature of fourteenth century England. Ball, along with Wat Tyler, was one of the principal leaders of the Peasants’ Revolt – his sermon ends: "I exhort you to consider that now the time is come, appointed to us by God, in which ye may (if ye will) cast off the yoke of bondage, and recover liberty". The subsequent events of June 1381 represent a pivotal and thrilling moment in England’s history, characterised by murder and mayhem, beheadings and betrayal, a boy-King and his absent uncle, and a general riot of destruction and death.

Every year on the fourth Thursday in November, Americans go home to their families and sit down to a meal. It’s called Thanksgiving and it echoes a meal that took place nearly 400 years ago, when a group of English religious exiles sat down, after a brutal winter, to celebrate their first harvest in the New World. They celebrated it in company with the American Indians who had helped them to survive. These settlers are called the Pilgrim Fathers and although they were not the first and certainly not the largest of the early settlements, they have retained a hold on the American imagination far out of proportion to their historical significance

The French mathematician Henri Poincaré declared: “The scientist does not study mathematics because it is useful; he studies it because he delights in it, and he delights in it because it is beautiful. And it is because simplicity, because grandeur, is beautiful that we preferably seek simple facts, sublime facts, and that we delight now to follow the majestic course of the stars.” Poincaré’s ground-breaking work in the 19th and early 20th century has indeed led us to the stars and the consideration of the shape of the universe itself.

Charles VI, a madman and the King of France, was dead and his kingdom hung in the balance. The French aristocracy were at war with each other, English soldiers occupied Paris and Charles’ crown was up for grabs, contested by his own son, the Dauphin, and the seven-year-old King of England, Henry VI. But as the English army pressed down through France, the only thing that seemed to stand between the English King and the French Crown was the city of Orleans.

The Spanish Civil War was a defining war of the twentieth century. It was a brutal conflict that polarised Spain, pitting the Left against the Right, the anti-clericals against the Church, the unions against the landed classes and the Republicans against the Monarchists. It was a bloody war which saw, in the space of just three years, the murder and execution of 350,000 people. It was also a conflict which soon became internationalised, becoming a battleground for the forces of Fascism and Communism as Europe itself geared up for war.

The Spanish Inquisition set up in 1478 surpassed all Inquisitorial activity that had preceded it in terms of its reach and length. For 350 years under Papal Decree, Jews, then Muslims and Protestants were put through the Inquisitional Court and condemned to torture, imprisonment, exile and death. How did the early origins of the Inquisition in Medieval Europe spread to Spain? What were the motivations behind the systematic persecution of Jews, Muslims and Protestants? And what finally brought about an end to the Spanish Inquisition 350 years after it had first been decreed?

On Monday September 10th 1792 The Times of London carried a story covering events in revolutionary France: "The streets of Paris, strewed with the carcases of the mangled victims, are become so familiar to the sight, that they are passed by and trod on without any particular notice. The mob think no more of killing a fellow-creature, who is not even an object of suspicion, than wanton boys would of killing a cat or a dog".

One night in Baghdad, the 9th century Caliph Al-Mamun was visited by a dream. The philosopher Aristotle appeared to him, saying that the reason of the Greeks and the revelation of Islam were not opposed. On waking, the Caliph demanded that all of Aristotle’s works be translated into Arabic. And they were.

Melvyn Bragg and guests discuss the history of mankind’s attempt to understand the nature of time. With Dr Neil Johnson, theoretical physicist at the Clarendon Laboratory, Oxford University and Royal Institution Christmas Lecturer 1999 on the subject of Time; Lee Smolin, cosmologist and Professor of Physics, Pennsylvania State University.

In 1928, as America heads towards the Wall Street Crash, Joseph Stalin reveals his master plan - nature is to be conquered by science, Russia to be made brutally, glitteringly modern and the world transformed by communist endeavour. Into the heart of this vision stepped Trofim Lysenko, a self-taught geneticist who promised to turn Russian wasteland into a grain-laden Garden of Eden.