Ester is about to turn forty and planning to celebrate the big birthday with all her friends and family. But the day before the party, she receives a phone call that will tip her life upside down.

Ester insists on one last magical night out with her closest friends before the cancer treatment begins. Unbeknown to all of them, Charlotte makes an unsettling discovery.

Ester prepares for chemotherapy, while Arild secretly struggles. Jørund develops health anxiety, and Finn decides it's time to turn his life around.

Ester starts undergoing chemotherapy as two of her closest friends tie the knot and her teenage son Lars also falls in love. Still convinced that there must be something wrong with him, Jørund orders a full medical examination.

The brutality of chemotherapy is now hitting hard and taking its toll on Ester. Jørund tries to make up with Charlotte after their bust-up but soon starts to suspect she may be hiding bigger secrets. Lars finally invites love interest Miko on a date.

Ester starts to wonder if she has it in her to continue with the harshness of her treatment, Arild is invited to Japan on a once-in-a-lifetime work trip, and Jørund gets a nasty shock.

There's a lot at stake in this final episode, as Ester gets to find out if the treatment she endured has worked or not, Jørund must decide if he intends to forgive Charlotte, and Finn reveals a big secret he's been carrying around for many years.