At Oxford's John Radcliffe Hospital, mum Adele has just heard the devastating news from brain surgeon Jay Jayamohan that her three-year-old daughter Cerys has a malignant brain cancer. This film follows Cerys's battle and shows other patients who are battling similar odds.

The brain is the most complex and mysterious organ in the body and the neurosurgeons of Oxford's John Radcliffe Hospital like Jay Jayamohan deal with brains which go badly wrong.

The parents of two year old Raj face an unimaginable dilemma. Ray has a brain tumour which, untreated, will kill him within months. Doctors at Oxford's John Radcliffe Hospital can operate but the surgery carries a high risk of paralysis.